Collagen Solution from human fibroblasts

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Cat NAT-0014
Cat.No. NAT-0014
Product Name Collagen Solution from human fibroblasts
Synonyms Collagen
Description Type I Collagen is a major structural component of skin, bone, tendon, and other fibrous connective tissues. It differs from other Collagens by its low lysine hydroxylation and low carbohydrate composition. Type I Collagen is a heterotrimer composed of two α1(I) chains and one alpha2(I) chain, which spontaneously form a triple helix scaffold at neutral pH and 37 °C.This product is prepared from the extracellular matrix secreted by normal human fibroblasts and contains a high monomer content. In vitro cultures were prepared using intensively tested human fibroblast cells and purified using a manufacturing process following applicable aspects of cGMP. This process contains built-in, validated steps to insure inactivation of possible prion and/or viral contaminants. Collagen is an essential ingredient of connective tissue. Studies in a Chinese family show that mutation in COL1A1 (Collagenase type I) is linked with type I osteogenesis imperfecta. Collagen is linked with subchondral turnover of bone, and might have potential as marker to determine the state of joint space narrowing and osteophytes in osteoarthritis.
Source human fibroblasts

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